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Codeine phosphate is a painkiller that is part of a group of medicines called opiates. It’s used to treat pain, for example, after an operation or an injury. It’s also used for ongoing pain when painkillers such as paracetamolibuprofen and aspirin have not worked. Codeine is also used to treat diarrhea.

It works in the central nervous system and the brain to block pain signals to the rest of the body. It also reduces the anxiety and stress caused by pain.

Codeine is available on prescription and comes as tablets, a liquid you swallow and as an injection. Codeine phosphate injections are usually only given in hospital.

You can also buy lower-strength codeine from a pharmacy. It comes mixed with paracetamol (co-codamol) or with aspirin (co-codaprin) or with ibuprofen (Nurofen Plus).

Pharmacies also sell codeine as a syrup (linctus) to treat dry coughs.

Key facts

  • The most common side effects of codeine are constipation, feeling sick (nausea) and feeling sleepy.
  • It’s possible to become addicted to codeine, but your doctor will explain how to reduce the risks of this happening.
  • If you need to take codeine for more than a few weeks, your treatment plan may include details of how and when to stop taking this medicine.
  • It may be best not to drink alcohol while taking codeine as you’re more likely to get side effects like feeling sleepy.
  • Do not give codeine to children under 12. Only give codeine to children aged 12 to 18 if everyday painkillers, like paracetamol and ibuprofen, have not worked.

See also Warning section. This medication is used to help relieve mild to moderate pain. codeine phosphate belongs to a class of drugs known as opioid analgesics. It works in the brain to change how your body feels and responds to pain.

How to use codeine phosphate

Read the Medication Guide provided by your pharmacist before you start taking codeine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor. You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea (such as lying down for 1 to 2 hours with as little head movement as possible).

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

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The dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed, because your risk of side effects may increase. Properly stop the medication when so directed.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

If you have ongoing pain (such as due to cancer), your doctor may direct you to also take long-acting opioid medications. In that case, this medication might be used for sudden (breakthrough) pain only as needed. Other pain relievers (such as acetaminophenibuprofen) may also be prescribed. Ask your doctor or pharmacist about using codeine safely with other drugs.

Suddenly stopping this medication may cause withdrawal, especially if you have used it for a long time or in high doses. To prevent withdrawal, your doctor may lower your dose slowly. Tell your doctor or pharmacist right away if you have any withdrawal symptoms such as restlessness, mental/mood changes (including anxiety, trouble sleeping, thoughts of suicide), watering eyesrunny nose, nausea, diarrheasweating, muscle aches, or sudden changes in behavior.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

Tell your doctor if your pain does not get better or if it gets worse.

If you are taking codeine phosphate to control a cough, tell your doctor if your cough does not get better in 5 days or if your condition gets worse.

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